Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin.
Mol Immunol
; 38(9): 701-8, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11858825
Nf1(-/-) fetal liver cells were used to reconstitute B and T cells in Rag-1(-/-) mice. Lymphocyte development was largely unimpaired in the absence of neurofibromin. However antigen-receptor induced proliferation was defective in neurofibromin deficient peripheral B cells and CD4(+) single positive thymocytes. In contrast to its role as a negative regulator of proliferation in many other cell types, neurofibromin may be a positive regulator of lymphocyte proliferation. Peripheral B cells exhibited circumscribed defects in anti-IgM induced protein tyrosine phosphorylation, which may contribute to the unexpected proliferative defect seen in these cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Linfócitos T CD4-Positivos
/
Neurofibromina 1
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos