[Blood coagulation in domestic deep-seated mycoses]. / Beobachtungen zur Blutgerinnung bei einheimischen tiefen Mykosen.
Mycoses
; 45 Suppl 1: 53-6, 2002.
Article
em De
| MEDLINE
| ID: mdl-12073564
ABSTRACT
Activation of blood coagulation to a varying extent affect the course of domestic invasive mycoses. Upon invasion of blood vessels by Candida or aspergilli, occasionally thrombi are formed, which may cause septic embolism. In the course of mucormycosis (syn. zygomycosis) thrombotic occlusion of afflicted blood vessels and subsequent necrosis of dependent tissue regularly occurs. Coagulation during candidosis or aspergillosis may be triggered by secreted aspartic proteinases which are able to activate factor X as has been shown previously [1, 2]. During mucormycosis, severe blood coagulation apparently is due to paracoagulation of fibrinogen which is triggered by low concentrations of extracellular fungal subtilisin-like proteinase (Arp). The enzyme is also able to inactivate the major inhibitor of blood coagulation (antithrombin III). Recent findings on the action of Arp are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coagulação Sanguínea
/
Transtornos da Coagulação Sanguínea
/
Micoses
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
De
Revista:
Mycoses
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Alemanha