Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones.
Org Lett
; 4(23): 4045-8, 2002 Nov 14.
Article
em En
| MEDLINE
| ID: mdl-12423082
ABSTRACT
In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 20001 are employed. [reaction see text]
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos