[Gemcitabine in elderly patients with unresectable pancreas cancer].
Gan To Kagaku Ryoho
; 29(13): 2521-5, 2002 Dec.
Article
em Ja
| MEDLINE
| ID: mdl-12506475
ABSTRACT
The efficacy and safety of gemcitabine at a starting dose of 1,000 mg/m2 administrated once a week for 3 weeks with 1 week's rest was investigated in elderly 11 patients with unresectable pancreatic cancer. Objective response was not documented. However, pain intensity, analgesic consumption and Karnofsky Performance Status (KPS) were frequently improved. In total, a clinical benefit was observed in 8 out of 11 (73%) patients. Toxicity was mild and well tolerated. These results suggest that gemcitabine had a superior clinical benefit and a mild toxicity profile. Gemcitabine should be the standard treatment in elderly patients with unresectable pancreatic cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Avaliação de Estado de Karnofsky
/
Desoxicitidina
/
Antimetabólitos Antineoplásicos
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
Ja
Revista:
Gan To Kagaku Ryoho
Ano de publicação:
2002
Tipo de documento:
Article