Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase.
J Investig Dermatol Symp Proc
; 7(1): 36-40, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12518790
ABSTRACT
The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queratinócitos
/
Proteínas Quinases Ativadas por Mitógeno
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Investig Dermatol Symp Proc
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos