Inclusion group systems and cis-trans effects in responses controlled by the two complementing Ir-GLphi genes.
J Exp Med
; 143(4): 889-96, 1976 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-1255115
The immune responses to the random linear terpolymers of L-amino acids, poly-(glu57, lys38, tyr5), poly-(glu51, lys34, tyr15,), and poly-(glu53, lys36, phe11) are each controlled by two dominant H-linked Ir genes. The immune responses to these three related terpolymers demonstrate different H-2 distributions, however, the H-2 patterns are part of a single inclusion group system. The alpha- and beta-genes are dominant; however, most effective gene interactions occur when the two genes are in the cis configuration. The potential significance of this cis-trans effect is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1976
Tipo de documento:
Article