In vitro metronidazole and tinidazole activities against metronidazole-resistant strains of Trichomonas vaginalis.

Crowell, Andrea L; Sanders-Lewis, Kolby A; Secor, W Evan

Crowell, Andrea L; Sanders-Lewis, Kolby A; Secor, W Evan.

Afiliação

Crowell AL; Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.

Antimicrob Agents Chemother ; 47(4): 1407-9, 2003 Apr.

Article em En | MEDLINE | ID: mdl-12654679

ABSTRACT

ABSTRACT

The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to metronidazole were compared. Minimal lethal concentrations (MLCs) of tinidazole were significantly lower than MLCs of metronidazole. Increased metronidazole resistance correlated with increased tinidazole resistance. These data support a role for tinidazole in the treatment of trichomoniasis.

Assuntos

Metronidazol/farmacologia; Tinidazol/farmacologia; Trichomonas vaginalis/efeitos dos fármacos; Animais; Resistência a Medicamentos; Feminino; Humanos; Vaginite por Trichomonas/tratamento farmacológico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tinidazol / Trichomonas vaginalis / Metronidazol Limite: Animals / Female / Humans Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Estados Unidos

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