Intercellular Interactions in the System of Hemopoietic Stem Cells.

ABSTRACT

Last years there are some reports about influence of erythron cells and immune system. It especially concerns with immunomodulation effect of cells of erythroid series and main humoral erythropoiesis regulator - erythropoietin. Much is known about the influence of cytokines of lymphoid and macrophagal origin on hemopoiesis, and in particular on erythroid compartment, and on functional activity of polypotent hematopoietic stem cell (PHSC). Published data allow to suggest the competitive relationships between erythroid and granulocyte-macrophagal series, and between erythroid and lymphoid series. Probably, interrelations between immune and erythroid systems are needed to consider from two points of view. First of all, cytokines should be considered as regulatory factors of proliferative and differentiated activity of both PHSC, and committed precursors of erythropoiesis. On the other hand, taking into account immunomodulating effects of erythroid cell series, the changes in erythron system during immunogenesis may be feedback mechanisms with immunoregulatory effect. All above gives principally new insights in the problem of regulation of immune system functions in norm and pathological states, as well as in the problem of immunocorrection of the latter, where factors, influencing on the intensity of erythropoiesis may be used as treatment agents.