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Relief of cough and nasal symptoms associated with allergic rhinitis by mometasone furoate nasal spray.
Gawchik, Sandra; Goldstein, Stanley; Prenner, Bruce; John, Ani.
Afiliação
  • Gawchik S; Asthma and Allergy Associates, Upland, Pennsylvania, USA. smgawchik@aol.com
Ann Allergy Asthma Immunol ; 90(4): 416-21, 2003 Apr.
Article em En | MEDLINE | ID: mdl-12722964
BACKGROUND: Cough commonly occurs as a symptom of seasonal allergic rhinitis (SAR), an inflammatory condition of the nasal mucous membranes that results in rhinorrhea, nasal stuffiness/congestion, nasal itching, and sneezing. Mometasone furoate nasal spray (MFNS, Nasonex, Schering, Kenilworth, NJ), an anti-inflammatory nasal corticosteroid, has been shown to be safe and effective in reducing the nasal inflammation of SAR. OBJECTIVE: To examine the effectiveness of MFNS in relieving SAR-associated cough, in addition to nasal symptoms. METHODS: This was a multicenter, randomized, double-blind study. Patients 12 years of age or older with > or = 1-year history of SAR symptoms, positive skin test to a prevailing seasonal allergen, moderate nasal symptoms, and moderate cough were treated for 14 days with MFNS 200 microg daily (n = 122) or placebo (n = 123). RESULTS: The group treated with MFNS showed significant improvement in the daytime cough severity score at endpoint compared with placebo (P = 0.049). Improvement in the nighttime cough severity score showed a trend in favor of MFNS treatment. Treatment with MFNS significantly improved total nasal symptoms in both the daytime and nighttime compared with placebo at endpoint (P < or = 0.017). Overall daytime symptom scores (cough + total nasal) improved significantly compared with placebo at endpoint (P = 0.005). Overall nighttime symptom scores improved significantly compared with placebo at endpoint (P = 0.028). Treatments were well tolerated, with no significant differences in the incidence of adverse events. CONCLUSIONS: MFNS is effective and well tolerated in the treatment of daytime cough associated with SAR.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pregnadienodiois / Prurido / Espirro / Descongestionantes Nasais / Obstrução Nasal / Rinite Alérgica Sazonal / Antialérgicos / Tosse / Anti-Inflamatórios Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Allergy Asthma Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pregnadienodiois / Prurido / Espirro / Descongestionantes Nasais / Obstrução Nasal / Rinite Alérgica Sazonal / Antialérgicos / Tosse / Anti-Inflamatórios Tipo de estudo: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Allergy Asthma Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Estados Unidos