Retroinverso analogue of the antiviral octapeptide C8 inhibits feline immunodeficiency virus in serum.
J Med Chem
; 46(10): 1807-10, 2003 May 08.
Article
em En
| MEDLINE
| ID: mdl-12723944
ABSTRACT
We described the antiviral activity of an octapeptide corresponding to a Trp-rich domain of feline immunodeficiency virus (FIV) transmembrane glycoprotein. To overcome the limited enzymatic stability of short peptides, the retroinverso analogue was prepared and tested for inhibitory activity of FIV in the presence or absence of normal cat serum. Differently from the unmodified peptide, the retroinverso analogue maintains strong inhibitory activity in serum. NMR studies showed that it displays crucial conformational features believed to be important for antiviral activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Oligopeptídeos
/
Glicoproteínas de Membrana
/
Proteínas dos Retroviridae
/
Vírus da Imunodeficiência Felina
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Itália