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Tc-99m-HMPAO uptake by bronchoalveolar cells.
Durak, Hatice; Kilinç, Oguz; Ertay, Türkan; Uçan, Eyüp Sabri; Kargi, Aydanur; Kaya, Gamze Capa; Sis, Banu.
Afiliação
  • Durak H; Department of Nuclear Medicine, Dokuz Eylül University School of Medicine, Inciralti, Izmir, Turkey. hatice.durak@deu.edu.tr
Ann Nucl Med ; 17(2): 107-13, 2003 Apr.
Article em En | MEDLINE | ID: mdl-12790358
Lung uptake of intravenously injected Tc-99m-HMPAO is observed in smokers and in lung toxicity due to various agents. We investigated the Tc-99m-HMPAO uptake of bronchoalveolar lavage (BAL) cells in the lungs after incubation in in vitro conditions (6 patients), intravenous injection (IV) (7 patients) and inhalation (INH) (6 patients) of Tc-99m-HMPAO in order to show whether BAL cells are also responsible for Tc-99m-HMPAO uptake in the lungs. Cell/supernatant (C/S) count ratio was 7.0 +/- 3.5, 29.3 +/- 40.8 and 8.4 +/- 4.5 for in vitro, IV and INH groups, respectively. C/Sin vitro showed a positive correlation with % alveolar macrophages (r = 0.943, p = 0.0048) and a negative correlation with % neutrophils (r = -0.945, p = 0.0045). Cells/whole BAL fluid ratio correlated with the amount of daily cigarette consumption in INH group (r = 0.95, p = 0.0037). Tc-99m-HMPAO showed adherence to mucus after inhalation. Tc-99m-HMPAO diffuses into alveolar spaces after injection and is present in BAL fluid and BAL cells both after injection and inhalation. Glutathione concentration and oxido-reductive state of the epithelial lining fluid and BAL cells may influence the lung uptake of Tc-99m-HMPAO.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido da Lavagem Broncoalveolar / Fumar / Compostos Radiofarmacêuticos / Tecnécio Tc 99m Exametazima Tipo de estudo: Clinical_trials Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Nucl Med Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Turquia
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido da Lavagem Broncoalveolar / Fumar / Compostos Radiofarmacêuticos / Tecnécio Tc 99m Exametazima Tipo de estudo: Clinical_trials Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Ann Nucl Med Assunto da revista: MEDICINA NUCLEAR Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Turquia