HtrA is a key factor in the response to specific stress conditions in Lactococcus lactis.
FEMS Microbiol Lett
; 224(1): 53-9, 2003 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-12855167
ABSTRACT
We investigated the physiological role of Lactococcus lactis housekeeping surface protease HtrA. It is involved in surface properties under regular growth conditions, as the htrA mutant strain forms longer chains in liquid medium. It participates in cellular defence against environmental stress conditions compared to the wild-type strain, the htrA mutant strain exhibited increased sensitivity to heat, ethanol, puromycin, and NaCl, but not to pH, H2O2, bile salts or to carbon or nitrogen starvation. htrA transcription in the wild-type strain showed a transient increase under stress conditions determined as requiring htrA, but not under overexpression of a secreted heterologous protein. Our results demonstrate that in L. lactis, htrA is a key factor in the response to specific stress conditions.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Serina Endopeptidases
/
Lactococcus lactis
/
Resposta ao Choque Térmico
/
Proteínas Periplásmicas
/
Proteínas de Choque Térmico
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
França