Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin.
Expert Rev Vaccines
; 2(2): 253-67, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12899576
ABSTRACT
The skin is an attractive target for vaccine delivery. Topical application of adjuvants results in potent immune responses and good safety profiles. Adjuvants can be coadministered in a patch with vaccine antigens (transcutaneous immunization) or similar delivery format, or administered separately with an injection or IS patch (Iomai), leading to enhanced immune responses. These observations have moved into the clinic, highlighting the likelihood that skin delivery of vaccines will play an important future role in vaccine applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Vacinas
/
Adjuvantes Imunológicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Vaccines
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos