Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions.
Am J Physiol Endocrinol Metab
; 285(4): E889-98, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-12959937
ABSTRACT
Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the CRF2R in skeletal muscle, we utilized CRFR knockout mice and CRF2R-selective agonists to modulate nerve damage and corticosteroid- and disuse-induced skeletal muscle atrophy in mice. These analyses demonstrated that activation of the CRF2R decreased nerve damage and corticosteroid- and disuse-induced skeletal muscle mass and function loss. In addition, selective activation of the CRF2R increased nonatrophy skeletal muscle mass. Thus we describe for the first time a novel activity of the CRF2R, modulation of skeletal muscle mass.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Hormônio Liberador da Corticotropina
/
Músculo Esquelético
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Am J Physiol Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
FISIOLOGIA
/
METABOLISMO
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos