[Effects of beta-agkistrodotoxin on synaptic transmission in toad sympathetic ganglia].
Sheng Li Xue Bao
; 44(2): 149-54, 1992 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-1320292
ABSTRACT
The effects of beta-agkistrodotoxin (beta-AgTX) on synaptic transmission of the toad sympathetic ganglia were investigated by intracellular recording techniques. Superfusion of beta-AgTX (30 microgram/ml, 5-15 min) reversibly inhibited the cholinergic fast excitatory postsynaptic potential (f-EPSP, n = 16) and the fast components of acetylcholine (ACh) potential induced by micropressure administration of ACh (n = 24). Comparison of beta-AgTX effect in the same cell group showed significantly different inhibition rates on f-EPSP (77.2 +/- 27.7%) and ACh potential (25.5 +/- 17.5%) (n = 6, P less than 0.01, F test). During application of beta-AgTX (30 or 50 micrograms/ml) for 15-30 min, no detectable change was found in non-cholinergic late slow EPSPs (n = 22). The results suggest that beta-AgTX selectively inhibits the cholinergic transmission of the toad sympathetic ganglia by both presynaptic and postsynaptic mechanism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transmissão Sináptica
/
Venenos de Crotalídeos
/
Gânglios Simpáticos
/
Neurotoxinas
Limite:
Animals
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Ano de publicação:
1992
Tipo de documento:
Article