Endocrine abortion in assisted reproduction technologies (ART).
Acta Biomed Ateneo Parmense
; 63(1-2): 113-24, 1992.
Article
em En
| MEDLINE
| ID: mdl-1340656
ABSTRACT
Luteal function, endometrial receptivity, endometrial prolactin and glycoprotein secretions, blastocyst-secreted immunomodulant factors and embryo quality are nowadays considered the main determinants involved in embryo implantation control. The endometrial factors are progesterone-dependent. Out of 128 cycles of ART (AIH-IU, GIFT, IVF-ET), performed in 67 women at the Dept. of Obstetrics and Gynaecology of Parma during the period 1986-1991, 31 conceptions were obtained (pregnancy rate 24.21%), 7 of which miscarried (abortion rate 22.58%). According to these data, ART high abortion rate is possibly connected with poor luteo-endometrial function and poor embryo quality. Controlled ovarian hyperstimulation is thought to inhibit embryo implantation after IVF-ET by decreasing endometrial receptivity. Such a situation can be treated either by exogenous progesterone administration or by tubal techniques (GIFT, TET) performed in non-tubal infertility. Both strategies showed to better endometrial receptivity. A delayed intrauterine embryo transfer at blastocyst stage, when cocultures allow to, is supposed to raise the implantation rate in tubal infertility by enhancing embryo selection and endometrial receptivity. This paper also reports preliminarily on the predictive value of beta-HGC and estradiol levels, as well as of endometrial thickness, on early pregnancy outcome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Reprodutivas
/
Infertilidade Feminina
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Acta Biomed Ateneo Parmense
Assunto da revista:
MEDICINA
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália