The human mast cell receptor binding site maps to the third constant domain of immunoglobulin E.
Mol Immunol
; 29(9): 1065-72, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1386650
ABSTRACT
The characterization of the site on the IgE molecule which accommodates the high affinity receptor for IgE (Fc epsilon RI) should allow the design of IgE analogues which can be utilized to block allergic responses. Using chimeric human IgE molecules in which different constant region domains were exchanged with their murine homologues, we demonstrate here that the C epsilon 3 in its native configuration is essential for the binding to the alpha subunit of the human Fc epsilon RI. Deletion of the human C epsilon 2 from such chimeric molecules did not impair their ability to interact with the Fc epsilon RI, indicating that C epsilon 2 is not directly involved in the human Fc epsilon RI binding site and that C epsilon 3 alone is necessary and sufficient to account for most of the human Fc epsilon RI-binding capacity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
/
Regiões Constantes de Imunoglobulina
/
Receptores Fc
/
Antígenos de Diferenciação de Linfócitos B
/
Mastócitos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Israel