Homoscalarane sesterterpenes from Lendenfeldia frondosa.
J Nat Prod
; 55(7): 859-65, 1992 Jul.
Article
em En
| MEDLINE
| ID: mdl-1402955
ABSTRACT
The marine sponge Lendenfeldia frondosa, collected from the Solomon Islands, has yielded homoscalarane sesterterpenes. Two new metabolites, epihomoscalaralactone IIA [5] and homoscalarate II [10], were accompanied by two known metabolites, homoscalaralactone IIA [1] and homoscalaralactone IIB [7]. These structures were established by analysis of 2D nmr data, trends in 13C-nmr shifts, and comparison of experimental with molecular-mechanics-calculated nmr J's. Each of the alcohols 1, 2, and 3 was converted to its corresponding acetate, 2, 6, and 8, respectively. Compound 6 exhibited moderate anti-inflammatory activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Terpenos
Limite:
Animals
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
1992
Tipo de documento:
Article