Activity of the thyroid parafollicular (C) cells in simple and hyperactive nodular goitre treated surgically - preliminary investigations.
Folia Morphol (Warsz)
; 62(4): 443-5, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14655137
ABSTRACT
The aim of this study was to evaluate the significance of measuring calcitonin (CT) plasma concentrations in patients with simple and hyperthyroid goitre treated surgically. Eighty four patients who underwent operations during the years 2000-2002 were analysed. Plasma concentrations of CT were determined by commercially available radioimmunoassay on the day of hospitalisation. Elevated concentrations of CT were found in 8 patients in 5 out of 26 (19.2%) and in 3 out of 33 (9.0%) patients with Graves' disease and with multinodular goitre, respectively. No major differences in concentrations of CT were observed in patients with simple goitre. Postoperative morphological analysis of pathologically changed hyperactive thyroids showed the presence of enlarged C cells distributed either in small groups or even singly with weakening immunohistochemical reaction for CT. These observations may point to the possibility of a relationship between the functional state of the thyroid gland and the activity of C cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Doença de Graves
/
Bócio Nodular
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Folia Morphol (Warsz)
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Polônia