In vitro evaluation of vascular endothelial growth factor (VEGF)-eluting stents.
Int J Cardiol
; 92(2-3): 247-51, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14659860
ABSTRACT
BACKGROUND:
Vascular endothelial growth factor (VEGF) is a specific endothelial cell mitogen. It promotes re-endothelialisation of the damaged vessel surface seen after stenting. Stent thrombosis and in-stent restenosis are partly related to endothelial denudation caused by stent implantation. We propose using hydrocarbon polymer-coated stents immersed in VEGF to speed re-endothelialisation and reduce the risk of stent thrombosis and restenosis.METHODS:
Stents (3 x 20 mm) were immersed in VEGF solutions and maximal VEGF absorption calculated. VEGF release from these stents was measured in a perfusion circuit. Delivery of VEGF to arterial wall was measured. Sterile VEGF-loaded stents were cultured with human umbilical vein endothelial cells.RESULTS:
18.5 +/- 4.1 microg VEGF was absorbed, 80% of which was released over 9 days; 11 +/- 6.8% of the initial VEGF loaded was delivered to the vessel wall. Cells exposed to VEGF-eluting stents showed an 11% increase in growth relative to controls.CONCLUSION:
VEGF may be a candidate for stent-based delivery and may increase the rate of endothelialisation in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Stents
/
Fator A de Crescimento do Endotélio Vascular
Limite:
Humans
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Reino Unido