Thalamic lesions in a long-surviving child with spinal muscular atrophy type I: MRI and EEG findings.
Brain Dev
; 26(1): 53-6, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14729416
ABSTRACT
Brain magnetic resonance imaging was conducted in a girl with genetically confirmed spinal muscular atrophy (SMA) type I. This patient has survived 6 years, to date, under mechanical ventilation. T2-weighted and fluid-attenuated inversion recovery images revealed high signal intensity lesions in the anterolateral portions of the bilateral thalami. Electroencephalography disclosed diffuse beta activity upon awakening and during light sleep. In addition, fast and prolonged spindles were observed. Although mild neuronal changes in the lateral nucleus of the thalamus have been described in several autopsied cases, this is the first study to demonstrate neuroradiologically and neurophysiologically the thalamic lesions in genetically confirmed SMA type I.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Atrofias Musculares Espinais da Infância
Tipo de estudo:
Diagnostic_studies
Limite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Brain Dev
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão