PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.
Science
; 303(5658): 685-9, 2004 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-14752163
ABSTRACT
Protein tyrosine kinases and phosphatases cooperate to regulate normal immune cell function. We examined the role of PEST domain-enriched tyrosine phosphatase (PEP) in regulating T cell antigen-receptor function during thymocyte development and peripheral T cell differentiation. Although normal naïve T cell functions were retained in pep-deficient mice, effector/memory T cells demonstrated enhanced activation of Lck. In turn, this resulted in increased expansion and function of the effector/memory T cell pool, which was also associated with spontaneous development of germinal centers and elevated serum antibody levels. These results revealed a central role for PEP in negatively regulating specific aspects of T cell development and function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Proteínas Tirosina Fosfatases
/
Memória Imunológica
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos