[Vincristine treatment for function- and life-threatening infantile hemangioma]. / Traitement par vincristine des hémangiomes graves du nourrisson.
Arch Pediatr
; 11(2): 99-107, 2004 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-14761730
ABSTRACT
AIM:
To evaluate the efficacy of vincristine treatment for function- and life-threatening hemangiomas. PATIENTS ANDMETHOD:
Nine infants, eight girls and one boy, received vincristine treatment (VCR) for endangering hemangiomas. In six cases, the hemangiomas involved head and neck in a segmental unilateral or bilateral distribution (3/6 also had laryngeal and 2/6 tracheal location causing respiratory distress, 5/6 had eyelid and orbital involvement); one infant had disseminated neonatal hemangiomatosis (skin, liver, kidney); two infants had liver hemangiomas with cardiac failure. VCR was prescribed after failure of high-dosage corticosteroid treatment in six, and of both corticosteroids and interferon alpha 2b (5 months) in one; two infants received VCR as first line treatment.RESULTS:
A dosage of 1 mg/m(2) IV injection was delivered, with weekly injections first, and then tapering, increasing the interval between injections, depending on the clinical response. The nine infants received from 5 to 25 injections (average 16), for a length of treatment of 1.5-8 months (average 5.5 months). In seven patients a clear clinical response was observed at the end of the first month of treatment, while a slow protracted response was noted in two. Transient mild side effects were present in four patients.DISCUSSION:
Corticosteroid treatment, although a worldwide recognized treatment of problematic hemangiomas, cannot always control the growth of alarming hemangiomas. Interferon alpha 2a and 2b have proven a 90% effectiveness treatment for cortico-resistant, function- and life-threatening, hemangiomas.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Vincristina
/
Hemangioma
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
Fr
Revista:
Arch Pediatr
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
França