Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling.
Science
; 303(5659): 836-9, 2004 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-14764879
ABSTRACT
Microtubule (MT) stabilization is regulated by the small guanosine triphosphate (GTP)-binding protein Rho and its effector, mammalian homolog of Diaphanous (mDia), in migrating cells, but factors responsible for localized stabilization at the leading edge are unknown. We report that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts. MT stabilization also involved FAK-regulated localization of a lipid raft marker, ganglioside GM1, to the leading edge. The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through GM1, or through a specialized membrane domain containing GM1, to stabilize MTs in the leading edge of migrating cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Integrinas
/
Membrana Celular
/
Proteínas rho de Ligação ao GTP
/
Microdomínios da Membrana
/
Microtúbulos
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos