Chitosan beads and granules for oral sustained delivery of nifedipine: in vitro studies.
Biomaterials
; 13(13): 949-52, 1992.
Article
em En
| MEDLINE
| ID: mdl-1477265
ABSTRACT
Nifedipine was embedded in a chitosan matrix to develop a prolonged-release form. The in vitro release profiles of nifedipine from chitosan beads and microgranules were monitored by UV spectrophotometer. The studies were performed in a rotating shaker (100 rev min-1) in 0.1 M HCl buffer (pH 2.0) or 0.1 M phosphate buffer (pH 7.4). Comparison was made between drug-loaded microbeads and microgranules. The amount and percentage of drug release were much higher in HCl than in phosphate buffer, probably due to the salt formation of the matrix (chitosan hydrochloride) at acid pH. The release rate of nifedipine from chitosan matrix was slower for beads than granules. These findings suggest the possibility of modifying the formulations to obtain the desired controlled release of the drug in an oral sustained-delivery system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Hemostáticos
/
Nifedipino
/
Quitina
/
Sistemas de Liberação de Medicamentos
Idioma:
En
Revista:
Biomaterials
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Índia