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Exploration of somatosensory P50 gating in schizophrenia spectrum patients: reduced P50 amplitude correlates to social anhedonia.
Arnfred, Sidse M; Chen, Andrew C N.
Afiliação
  • Arnfred SM; Department of Psychiatry, Hvidovre Hospital, University Hospital of Copenhagen, Brøndbyøstervej 160, DK-2605 Brøndby, Denmark. s.arnfred@tdcadsl.dk
Psychiatry Res ; 125(2): 147-60, 2004 Feb 15.
Article em En | MEDLINE | ID: mdl-15006438
ABSTRACT
Originally, the hypothesis of a sensory gating defect in schizophrenia evolved from studies of somatosensory evoked potentials (SEP), although the idea has primarily been pursued in the auditory modality. Gating is the relative attenuation of amplitude following the second stimulus in a stimulus pair. Recently, SEP P50 gating was seen when recording the SEP P50 in a paradigm similar to the one used for auditory P50 gating. Hypothetically, abnormality of somatosensory information processing could be related to anhedonia, which is considered a core feature of schizophrenia. Twelve unmedicated, male, schizophrenia spectrum patients (seven schizophrenic and five schizotypal personality disorder patients) and 14 age-matched healthy men participated in recordings of pair-wise presented auditory and median nerve stimuli. The patients had smaller amplitudes of the SEP P50 at the first stimulus, but no gating defect. The reduced amplitude was particularly evident in subjects with high scores on the Revised Social Anhedonia Scale. Early somatosensory information processing seems abnormal in schizophrenia spectrum patients. This could be in agreement with the theory of loss of the benefit of regularity in schizophrenia, while the results are in-conclusive regarding sensory gating theory.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Comportamento Social / Potenciais Somatossensoriais Evocados Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Psychiatry Res Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Dinamarca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Comportamento Social / Potenciais Somatossensoriais Evocados Tipo de estudo: Diagnostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Psychiatry Res Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Dinamarca