MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.
FEBS Lett
; 561(1-3): 37-43, 2004 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-15013748
ABSTRACT
Influenza A and B viruses are still a major worldwide threat. We demonstrate that influenza B virus infection induces signaling via the Raf/MEK/ERK cascade, a process required for efficient virus production. Expression of dominant-negative Raf and ERK mutants or treatment with a MEK inhibitor (U0126) strongly impaired viral propagation, while selective activation of the pathway resulted in increased virus titers. MEK inhibition appears to interfere with a distinct viral nuclear export process. Most importantly, no resistant virus variants emerged in the presence of U0126 demonstrating that influenza viruses cannot easily adapt to the missing cellular function.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus da Influenza B
/
Replicação Viral
/
Quinases de Proteína Quinase Ativadas por Mitógeno
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha