Viral and cellular kinases are potential antiviral targets and have a central role in varicella zoster virus pathogenesis.
Biochim Biophys Acta
; 1697(1-2): 225-31, 2004 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-15023363
ABSTRACT
Herpesviruses utilize viral and cellular kinases for replication, and these mediate essential functions that are important for viral pathogenesis. Elucidating the roles of kinases in herpesvirus infections may highlight virus-host interactions that are possible targets for kinase inhibitors with antiviral activity. Varicella zoster virus (VZV) encodes two kinases that phosphorylate viral proteins involved in regulation, assembly, and virulence. VZV infection also induces the activity of host cell cyclin-dependent kinases (cdk4 and cdk2) in nondividing cells, causing a disregulation of the cell cycle. Roscovitine and Purvalanol, kinase inhibitors that target cdks, prevent VZV replication at concentrations with few cytotoxic effects. Cdk inhibitors therefore have potential as antivirals that may extend to a broad range of viruses and have the added advantage that resistance does not arise easily.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Herpesvirus Humano 3
/
Quinases Ciclina-Dependentes
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos