Does increasing the steroid dose enhance the efficacy of the antiemetic combination of granisetron and methylprednisolone in gynecologic cancer patients--a randomized study.
Eur J Obstet Gynecol Reprod Biol
; 113(1): 94-7, 2004 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-15036719
ABSTRACT
OBJECTIVE:
The authors administered two doses of oral methylprednisolone in combination with 3mg granisetron intravenously for the prophylaxis of cisplatin-induced emesis in gynecologic cancer patients. MATERIALS ANDMETHODS:
Thirty-nine patients received 100mg (group A) and 25 received 200mg (group B) methylprednisolone in the antiemetic combination in a randomized prospective trial.RESULTS:
No vomiting in 90.2 and 96.7%, one emetic episode in 3 and 1.1% and two episodes in 3 and 2.2% were detected in groups A and B, respectively. More than two emetic episodes were considered to be a failure and were observed only in group A (3.8%). There was no significant difference between the two treatment groups (P=0.3160).CONCLUSIONS:
There was no evidence for enhanced antiemetic effect of elevated steroidal dose in combination with granisetron.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vômito
/
Metilprednisolona
/
Granisetron
/
Antieméticos
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Hungria