Long-term immunity to measles, mumps and rubella after MMR vaccination among children with bone marrow transplants.
Bone Marrow Transplant
; 33(12): 1187-90, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15077129
ABSTRACT
Measles, mumps and rubella (MMR) vaccine-induced long-term immunity was studied in 30 children with bone marrow transplants (BMT). Immunity at baseline for MMR was 13.3, 33.3 and 66.6%, respectively. MMR vaccination failed to induce adequate and persistent responses to measles and mumps; seropositivity at 1 and 12 months for measles was 26.6 and 23.3% and for mumps 46.6 and 36.6%, respectively. In contrast, 27 of 30 children with a BMT were immune to rubella 1 month after immunization and retained protective antibody levels at 12 months. The MMR-induced anamnestic responses to rubella among all responders were associated with the production of high avidity antibodies. We conclude that a single dose of MMR given at 2 years after BMT induces suboptimal and short-lived immune responses to measles and mumps; a second dose should be recommended for paediatric BMT recipients.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rubéola (Sarampo Alemão)
/
Transplante de Medula Óssea
/
Vacina contra Sarampo-Caxumba-Rubéola
/
Sarampo
/
Formação de Anticorpos
/
Caxumba
Tipo de estudo:
Etiology_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Bone Marrow Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Grécia