Synthesis, radioiodination, and biodistribution of some nido- and closo-monocarbon carborane derivatives.
Nucl Med Biol
; 31(4): 523-30, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15093823
ABSTRACT
Iodination and radioiodination reactions of several anionic nido- and closo-monocarbon carboranes were conducted. Iodinations occurred more rapidly with nido-carboranes than with closo-carboranes. The most rapid iodination and radioiodination reactions occurred with unsubstituted carboranes. C-amino and C-ammonium derivatives did not iodinate under the conditions studied. Both nido- and closo-carboranes with C-NH-acetyl and C-NH-succinyl substituents iodinated, but the nido-carboranes iodinated under milder reaction conditions. Biodistributions of nido-1-succinylamido-[(131)I]carborane and closo-1-succinylamido-[(125)I]carborane were similar in mice, but blood clearance of the nido- compound was slower.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Boranos
/
Radioisótopos do Iodo
Tipo de estudo:
Evaluation_studies
Limite:
Animals
Idioma:
En
Revista:
Nucl Med Biol
Assunto da revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos