A polymorphic complex dinucleotide repeat at the telomeric D8S7 locus.
Hum Hered
; 42(3): 149-52, 1992.
Article
em En
| MEDLINE
| ID: mdl-1511991
ABSTRACT
Two cosmids isolated from a flow-sorted chromosome 8 library by hybridization with pSW50 (D8S7) were screened for GT microsatellite sequences. Both contained a positive 900-bp Hind III-Xba I fragment. Sequencing revealed a complex dinucleotide repeat. Flanking oligonucleotide primers were synthesized, and the polymerase chain reaction products produced by these primers were typed within the CEPH panel of families. A two-allele polymorphism was identified that is in linkage disequilibrium with a previously described insertion-deletion polymorphism at this locus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Polimorfismo Genético
/
Cromossomos Humanos Par 8
/
Telômero
Limite:
Humans
Idioma:
En
Revista:
Hum Hered
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Canadá