Triazolam suppresses the induction of hippocampal long-term potentiation.
Neuroreport
; 15(7): 1145-9, 2004 May 19.
Article
em En
| MEDLINE
| ID: mdl-15129163
ABSTRACT
Benzodiazepines are sedative hypnotics that produce marked anterograde amnesia in humans. These pharmacological properties are thought to result from the potentiation of GABA-A receptor function and subsequent attenuation of long-term potentiation (LTP), however many reports have suggested this is not the case for triazolam. Using electrophysiological recordings in a cell line expressing recombinant GABA-A receptors, we confirm that triazolam is an efficacious positive allosteric modulator of GABA-A receptors. Triazolam also slowed the decay of spontaneous inhibitory synaptic currents, reduced the amplitude of fEPSPs elicited during a theta burst and reduced the magnitude of LTP in hippocampal CA1 neurones in vitro. These data show that triazolam modifies LTP induction consistent with an enhancement of GABA-A receptor function via activation of the allosteric benzodiazepine-site.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazolam
/
Potenciação de Longa Duração
/
Hipocampo
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido