Ligand-independent tonic signaling in B-cell receptor function.
Curr Opin Immunol
; 16(3): 288-95, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15134777
ABSTRACT
The random and inherently imprecise process of V(D)J recombination is the foundation for generation of the B-cell receptor (BCR). Signals must be generated to trigger selective processes that retain cells expressing a functional BCR, and these signals must be antigen-independent to insure an unbiased and diverse pool of newly formed B cells. Moreover, BCR expression, and presumably signaling, is essential for the continued survival of the B cell. Although BCR signaling is generally thought to depend upon ligand-induced aggregation, recent studies argue that some aspects of BCR signaling occur independently of antigen, and, furthermore, these non-induced or 'tonic' signals are linked to specific cellular processes operating at multiple stages of B-cell development. The potential co-existence of tonic and induced signaling suggests a unique aspect of BCR complexes, or at least an aspect of receptors that has previously been under-appreciated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recombinação Genética
/
Linfócitos B
/
Ativação Linfocitária
/
Receptores de Antígenos de Linfócitos B
/
Transdução de Sinais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos