Your browser doesn't support javascript.
loading
[Mutations of the androgen receptor gene in patients with clinically localized adenocarcinoma of the prostate]. / Mutaciones del gen del receptor de andrógenos en pacientes con adenocarcinoma de próstata clínicamente localizado.
Sánchez Zalabardo, D; Rosell Costa, D; Honorato Cia, B; Rioja Zuazu, J; Regojo Balboa, J M; Fernández Montero, J M; López Ferrandis, J; Robles García, J E; Zudaire Bergera, J J; García Foncillas, J; Berián Polo, J M.
Afiliação
  • Sánchez Zalabardo D; Departamento de Urología, Clínica Universitaria, Universidad de Navarra, Pamplona.
Actas Urol Esp ; 28(3): 221-9, 2004 Mar.
Article em Es | MEDLINE | ID: mdl-15141419
UNLABELLED: The aim of this study was to detect mutations in the human androgen receptor gene in radical prostatectomy specimens. MATERIAL AND METHODS: The genomic sequence was realized in 67 radical prostatectomy specimens. The mean age was 64 years old. The PSA median was 15 ng/ml. TNM 1997: 34.3% were T1 and 65.7% T2. Genomic sequence: 1. Radical prostatectomy specimens desparaffitation. 2. Extraction of the DNA 3. DNA amplification. 4. Automatic genome sequence. 5. Comparison with Gene-Bank. RESULTS: 16.7% of the specimens were mutated. The most frequent mutation was the punctual mutation. The exon most frequent mutated was exon 1.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Receptores Androgênicos / Mutação Limite: Aged / Humans / Male / Middle aged Idioma: Es Revista: Actas Urol Esp Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Adenocarcinoma / Receptores Androgênicos / Mutação Limite: Aged / Humans / Male / Middle aged Idioma: Es Revista: Actas Urol Esp Ano de publicação: 2004 Tipo de documento: Article