Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples.
Lancet
; 363(9427): 2137-9, 2004 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-15220037
ABSTRACT
Factors that might increase risk of HIV-1 transmission include age, sex, and amount of HIV-1 RNA in plasma, but findings for HLA allele-sharing are not in agreement. We tested the hypothesis that allele sharing at HLA loci is associated with increased risk of transmission of HIV-1 infection in cohabiting heterosexual Zambian couples. We studied 125 initially serodiscordant partners with sequence-confirmed interpartner HIV-1 transmission and 104 couples who were persistently serodiscordant, and we analysed relations with molecularly typed HLA-A, B, and C alleles by survival techniques. After adjustment for other genetic and non-genetic risk factors seen with heterosexual transmission of HIV-1 in this cohort, sharing of HLA-B alleles was independently associated with accelerated intracouple transmission (relative hazard 2.23, 95% CI 1.52-3.26, p<0.0001). Selective pressure by HLA-B alleles on transmitted viruses accords with current understanding of the effect of B locus polymorphism in HIV-1 and perhaps other infections.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parceiros Sexuais
/
Antígenos HLA-B
/
Infecções por HIV
/
HIV-1
/
Heterossexualidade
/
Alelos
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Lancet
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos