Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide (CGRP), calcitonin (CT), somatostatin (SST) and synaptophysin (SYN) in the C cells of the rat thyroid--a preliminary study.
Folia Morphol (Warsz)
; 63(2): 217-19, 2004 May.
Article
em En
| MEDLINE
| ID: mdl-15232780
ABSTRACT
The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl2 iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl2, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Cádmio
/
Calcitonina
/
Somatostatina
/
Peptídeo Relacionado com Gene de Calcitonina
/
Sinaptofisina
Limite:
Animals
Idioma:
En
Revista:
Folia Morphol (Warsz)
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Polônia