GAP control: regulating the regulators of small GTPases.
Trends Cell Biol
; 14(7): 377-85, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15246431
ABSTRACT
The small GTPases of the Ras superfamily mediate numerous biological processes through their ability to cycle between an inactive GDP-bound and an active GTP-bound form. Among the key regulators of GTPase cycling are the GTPase-activating proteins (GAPs), which stimulate the weak intrinsic GTP-hydrolysis activity of the GTPases, thereby inactivating them. Despite the abundance of GAPs and the fact that mutations in GAP-encoding genes underlie several human diseases, these proteins have received relatively little attention. Recent studies have addressed the regulatory mechanisms that influence GAP activity. So far, findings suggest that GAP activity is regulated by several mechanisms, including protein-protein interactions, phospholipid interactions, phosphorylation, subcellular translocation and proteolytic degradation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Ativadoras de GTPase
/
GTP Fosfo-Hidrolases
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos