New cytotoxic cembranes from the sea pen Gyrophyllum sibogae.
J Nat Prod
; 67(7): 1190-2, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15270580
ABSTRACT
Two new cembrane-type diterpenoids have been isolated from the 2-propanol extract of the sea pen Gyrophyllum sibogae collected in South Africa 7,8-dihydroflabellatene A (1) and 7,8-dihydroflabellatene B (2). Their structures were determined on the basis of detailed spectroscopic analysis and by single-crystal X-ray analysis of the major metabolite 1, which showed strong in vitro cytotoxicity against a panel of 13 tumor cell lines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antozoários
/
Diterpenos
/
Antineoplásicos
Limite:
Animals
/
Humans
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Espanha