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Autoimmunity and atopic dermatitis.
Mittermann, Irene; Aichberger, Karl J; Bünder, Robert; Mothes, Nadine; Renz, Harald; Valenta, Rudolf.
Afiliação
  • Mittermann I; Department of Pathophysiology, Division of Immunopathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.
Curr Opin Allergy Clin Immunol ; 4(5): 367-71, 2004 Oct.
Article em En | MEDLINE | ID: mdl-15349035
ABSTRACT
PURPOSE OF REVIEW It has been demonstrated that a considerable percentage of patients suffering from atopic dermatitis mount IgE autoantibodies against a broad variety of human proteins. This review summarizes evidence for autoimmune mechanisms in atopic dermatitis and suggests novel pathomechanisms that may be involved in this disease. RECENT

FINDINGS:

It has been shown that patients suffering from atopic dermatitis exhibit IgE autoreactivity to human proteins. These autoantigens are expressed in a variety of cell and tissue types. Complementary DNAs coding for IgE autoantigens have been identified, cloned and characterized at the molecular level. Using purified recombinant IgE autoantigens, it has been shown in paradigmatic models that IgE autoimmunity may be a pathogenetic mechanism in atopic dermatitis. Moreover, it has been shown that the levels of IgE autoantibodies are associated with severity of disease.

SUMMARY:

Patients suffering from severe manifestations of atopy mount IgE autoantibodies against a variety of human proteins. The levels of IgE autoantibodies correspond with disease severity. Several mechanisms of IgE autoimmunity may contribute to the pathogenesis of atopic dermatitis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoimunidade / Dermatite Atópica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Curr Opin Allergy Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Áustria
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoimunidade / Dermatite Atópica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Curr Opin Allergy Clin Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Áustria