Expression of atrial natriuretic peptide in thymic macrophages after dexamethasone treatment of rats.
Cell Tissue Res
; 268(2): 397-9, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1535554
ABSTRACT
The rat thymus represents a site of synthesis of atrial natriuretic peptide (ANP); the immunosuppressor dexamethasone strikingly increases ANP-expression in this immune organ. The presented data suggest that this increase can be attributed to macrophages. By means of immunohistochemistry and Northern blot analysis these immune cells were found to express ANP-immunoreactivity as well as mRNA coding for ANP. In contrast, macrophages of control thymi displayed only weak ANP-immunoreactivity. Thus, ANP appears to be a constituent of rat thymic macrophages, and its synthesis in the thymus is strongly elevated by acute exposure of the animals to glucocorticoids.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Dexametasona
/
Fator Natriurético Atrial
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Cell Tissue Res
Ano de publicação:
1992
Tipo de documento:
Article