Contribution of rod and cone pathways to the dark-adapted electroretinogram (ERG) b-wave following retinal degeneration in RCS rats.
Vision Res
; 44(21): 2467-74, 2004.
Article
em En
| MEDLINE
| ID: mdl-15358082
ABSTRACT
Although the RCS rat is widely used as a model of progressive photoreceptor loss, it is unclear how the relative rod and cone functions change with age. Rod and cone b-waves were isolated using a double flash ERG paradigm. In contrast to cones, rods never reached normal functional maturity levels, and the ERG b-wave changed from being predominantly rod-driven to being purely cone-driven by age 74 days, at which point, b-waves were progressively replaced by negative STR-like (scotopic threshold response) waves that persisted up to age 180 days. A double flash commonly abolished this wave and unveiled a b-wave.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Degeneração Retiniana
/
Células Fotorreceptoras Retinianas Bastonetes
/
Células Fotorreceptoras Retinianas Cones
/
Adaptação à Escuridão
Limite:
Animals
Idioma:
En
Revista:
Vision Res
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos