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Contribution of rod and cone pathways to the dark-adapted electroretinogram (ERG) b-wave following retinal degeneration in RCS rats.
Pinilla, I; Lund, R D; Sauvé, Y.
Afiliação
  • Pinilla I; Moran Eye Center, Ophthalmology and Visual Sciences, University of Utah, 75 North Medical Drive, Salt Lake City, UT 84132, USA.
Vision Res ; 44(21): 2467-74, 2004.
Article em En | MEDLINE | ID: mdl-15358082
ABSTRACT
Although the RCS rat is widely used as a model of progressive photoreceptor loss, it is unclear how the relative rod and cone functions change with age. Rod and cone b-waves were isolated using a double flash ERG paradigm. In contrast to cones, rods never reached normal functional maturity levels, and the ERG b-wave changed from being predominantly rod-driven to being purely cone-driven by age 74 days, at which point, b-waves were progressively replaced by negative STR-like (scotopic threshold response) waves that persisted up to age 180 days. A double flash commonly abolished this wave and unveiled a b-wave.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Células Fotorreceptoras Retinianas Bastonetes / Células Fotorreceptoras Retinianas Cones / Adaptação à Escuridão Limite: Animals Idioma: En Revista: Vision Res Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Células Fotorreceptoras Retinianas Bastonetes / Células Fotorreceptoras Retinianas Cones / Adaptação à Escuridão Limite: Animals Idioma: En Revista: Vision Res Ano de publicação: 2004 Tipo de documento: Article País de afiliação: Estados Unidos