Dementia following posterior cortical atrophy--a descriptive clinical case report.

ABSTRACT

Whether posterior cortical atrophy is a distinct entity or a variant of one of the other degenerative processes continues to be debated. We describe five patients four of whom had bilateral changes of posterior cortical atrophy on the CT scan. These four had a cluster of symptoms consistent with parieto-occiptial dysfunction together with a spectrum of dementia. The fifth patient with unilateral changes had optic ataxia, apraxia of gait and dementia. Three of the five patients were heavy drinkers of alcohol but any direct causal link between alcohol and posterior cortical atrophy is tenuous but alcohol could be a consideration in lowering the threshold for dementia in conjunction with other determinants. The study revealed there is little or no difficulty in recognizing posterior cortical atrophy in the early stages and the end stages are sufficiently uniform to reduce the diagnostic uncertainty.