Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.
Fertil Steril
; 82(4): 857-62, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15482760
ABSTRACT
OBJECTIVE:
To enable serodiscordant couples to reproduce while minimizing the risk of infecting the female partner and to demonstrate the feasibility of including these couples in an insemination program.DESIGN:
Prospective follow-up study.SETTING:
Ambulatory IUIs. PATIENT(S) Fifty-six HIV-1-serodiscordant couples with a male infected partner. INTERVENTION(S) Sperm cell separation by the gradient density method followed by the swim-up method, virological detection, and IUI after ovarian stimulation. MAIN OUTCOME MEASURE(S) Pregnancy rate, HIV-1 test, and p24 antigenemia in women. RESULT(S) Two hundred thirteen IUIs were performed, and 37 pregnancies occurred, resulting in 33 births and 2 ongoing pregnancies. Fifty percent of couples have a child. No women were infected. CONCLUSION(S) Our study demonstrates the efficiency of an IUI program with prepared and virologically tested spermatozoa in serodiscordant couples with an HIV-1-infected male partner, allowing the couples to have children without transmission of the virus to the female partner.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
/
Infecções por HIV
/
HIV-1
/
Inseminação Artificial Homóloga
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
França