Attempted suicide by ingestion of chlorpyrifos: identification in serum and gastric content by GC-FID/GC-MS.
J Anal Toxicol
; 28(7): 609-15, 2004 Oct.
Article
em En
| MEDLINE
| ID: mdl-15516321
ABSTRACT
A mild case of self-poisoning with a chlorpyrifos formulation following oral ingestion is reported. A 15-year-old female went to the emergency room after the ingestion of a product from a bottle marked with a label "Poison". On admission, she was obtunded, with normal vital signs and a strong smell of solvent. Therapeutic measures included the application of decontamination procedures, oxygen, and gastric protectors. She had a good outcome with mild CNS depression and bradycardia. Two hours after ingestion, biological samples were collected in the emergency room and sent for analysis to our laboratory with instructions to investigate the presence of solvents. The serum and gastric content contained 5.3 and 9.4 microg/mL of unmetabolized chlorpyrifos, 4.6 and 6.9 microg/mL of toluene, and 2.5 and 7.9 microg/mL of butyl acetate, respectively. Small traces of other solvents and tetradifon were also detected. Toxicological analyses were negative for ethanol, other volatile solvents, and common drugs of abuse. The simultaneous determination of chlorpyrifos, toluene, and butyl acetate was performed using the combination of gas chromatography (GC)-flame ionization detection for screening analysis and GC-mass spectrometry for confirmation of the obtained results. The method provides an excellent and rapid tool for use in cases of pesticide poisonings, allowing the simultaneous detection of the pesticide and distillates in the performance of systematic toxicological analysis in forensic and clinical laboratories.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clorpirifos
/
Medicina Legal
/
Conteúdo Gastrointestinal
/
Inseticidas
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adolescent
/
Female
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Anal Toxicol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Espanha