In vitro effects of pentosan polysulfate against malignant breast cells.
Am J Surg
; 188(5): 589-92, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15546576
ABSTRACT
BACKGROUND:
Pentosan polysulfate (Elmiron); (Alza Pharmaceuticals, Mountain View, CA) is the only Food and Drug Administration-approved oral therapy for interstitial cystitis (IC). Women with IC and breast cancer are often in the same age range; therefore, we hypothesize that pentosan polysulfate may also have a therapeutic effect on breast cancer cells in vitro.METHODS:
Breast cancer lines MCF-7, ZR75-1, and HTB26 were treated with pentosan polysulfate at various concentrations. Cell viability was measured at 24 hours by MTT. Annexin V assay was used to determine the effect of pentosan polysulfate on apoptotic and necrotic activity.RESULTS:
Pentosan polysulfate significantly inhibited the growth of the ZR75-1 cells; however, significant cellular proliferation was observed in the MCF-7 cells. A significant change in late apoptotic activity was observed with pentosan polysulfate treatment in vitro.CONCLUSIONS:
Caution should be used in prescribing pentosan polysulfate for the treatment of IC in patients who are both in high-risk groups for breast cancer and premenopausal females.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliéster Sulfúrico de Pentosana
/
Apoptose
/
Proliferação de Células
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Am J Surg
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos