Antiviral and antiplasmodial spirodihydrobenzofuran terpenes from the fungus Stachybotrys nephrospora.
Planta Med
; 70(11): 1085-7, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15549667
Two known spirodihydrobenzofuran terpenes (1 and 2) were isolated from a mycelium extract of the fungus Stachybotrys nephrospora BCC 3900. Compound 1 (Mer-NF5003F or stachybotrydial) exhibited potent antiviral activity (the IC50 value of 4.32 microg/mL) comparable to the standard drug, acyclovir, while compound 2 was inactive against the HSV-1 virus. Both 1 and 2 possessed antiplasmodial activity (IC50 values of 0.85 and 0.15 microg/mL for 1 and 2, respectively), and were not toxic towards the Vero cell line. A regiospecific conversion of the dialdehyde 1 to the lactone 2 proceeded simply under acidic conditions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Plasmodium falciparum
/
Stachybotrys
/
Extratos Vegetais
/
Herpesvirus Humano 1
/
Fitoterapia
/
Antimaláricos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Tailândia