Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Burrows, Jeremy N; Cumming, John G; Fillery, Shaun M; Hamlin, Gordon A; Hudson, Julian A; Jackson, Ruth J; McLaughlin, Sharon; Shaw, John S

Burrows, Jeremy N; Cumming, John G; Fillery, Shaun M; Hamlin, Gordon A; Hudson, Julian A; Jackson, Ruth J; McLaughlin, Sharon; Shaw, John S.

Afiliação

Burrows JN; Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.

Bioorg Med Chem Lett ; 15(1): 25-8, 2005 Jan 03.

Article em En | MEDLINE | ID: mdl-15582404

RESUMO

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.

Assuntos

Amidas/química; Piperidinas/farmacologia; Receptores CCR5/efeitos dos fármacos; Ureia/química; Humanos; Piperidinas/química; Relação Estrutura-Atividade

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Ureia / Receptores CCR5 / Amidas Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2005 Tipo de documento: Article

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