Mouse brain organization revealed through direct genome-scale TF expression analysis.
Science
; 306(5705): 2255-7, 2004 Dec 24.
Article
em En
| MEDLINE
| ID: mdl-15618518
ABSTRACT
In the developing brain, transcription factors (TFs) direct the formation of a diverse array of neurons and glia. We identifed 1445 putative TFs in the mouse genome. We used in situ hybridization to map the expression of over 1000 of these TFs and TF-coregulator genes in the brains of developing mice. We found that 349 of these genes showed restricted expression patterns that were adequate to describe the anatomical organization of the brain. We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Encéfalo
/
Genoma
/
Perfilação da Expressão Gênica
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Science
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos