The role of IFN-gamma in cattle infected with Theirelia sergenti.
Vet Parasitol
; 127(2): 105-10, 2005 Jan 20.
Article
em En
| MEDLINE
| ID: mdl-15631902
ABSTRACT
The spleen plays an important role in cellular immunity leading to parasite elimination, especially in hemo-protozoan parasite infection. In the present study, we quantified the serum IFN-gamma in splenectomized (SP) and non-splenectomized (NSP) cows infected with Theirelia sergenti (TS) to investigate whether the spleen plays a role in the Th1-type cytokine responses in cows following parasite infection. A transient increase in IFN-gamma was observed in the early stages of infection in the NSP cows, and the cows did not develop parasitemia. In contrast, the SP cows showed no IFN-gamma response at the early stage of infection, and the cows developed parasitemia following anemia. The NSP cows produced IgG1 and IgG2 antibodies to TS-specific, whereas the SP cows showed increases only in IgG1. Increased PBMC proliferation by cocanavalin A stimulation was observed concomitant with the IFN-gamma response. Pretreatment with IFN-gamma suppressed the propagation of TS in the SP cattle. These results suggest that the spleen plays an important role in the resistance to TS infection, leading to a Th1-type immune response. IFN-gamma might contribute to the activation of immunocytes and play an important role in the immune response to resist TS proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Theileriose
/
Doenças dos Bovinos
/
Interferon gama
/
Theileria
Limite:
Animals
Idioma:
En
Revista:
Vet Parasitol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão